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Highlights

Review & Testimonials/Case Examples

Research

Introduction About the Topic

Current Treatments and Side Effects

How stem cells & Other Treatments Work

Highlights of Our Facility

FAQs

WOUND AND ULCER HEALING

Highlights

Safe Non Invasive & Natural Option*

Avoid surgery toxic medications and injections.

Stimulates the Body’s Own Healing Ability*

Helps balance body in a process called regeneration.*

Preventing inflammation.

A Natural Treatment*

No down time.

Return to work the same day.   

 

Ongoing Research Participation

We enroll our patients in ongoing research protocols and data system for collection & analysis of best outcome results from therapies. We keep records of procedures performed in our outcomes database & in shared and published databases. Patients are always treated with the best protocols & treatments based on the latest research data & informed consent on investigational nature of treatments.  Strict sterile protocols & universal precautions are followed by out office and staff.

The Difference

Treatments at Other Clinics:

"Patch up" treatments like, addicting pain medications, Steroid injection, Medications (with many side effects including weight gain & increased blood sugar, damage to kidneys, heart, stroke & gastric ulcer from NSAIDs.)

Not experienced in management of chronic diseases.

May not offer option of different bone marrow types. (only offer drilling bones or low quality umbilical stem cells.)

May use poorly trained non-physician assistants to evaluate & perform injections.

Not FDA compliant.

Treatments at Our Clinic:

Treating the root cause of the problem by regenerating the damaged regions and balancing immune system. Good safety profile with body products from own body.

Other modalities like IV Vitamin Therapy to focus on the whole body and treating different parts of it instead of just treating one out of several diseased structures in the body.

Several types of stem cell including Adipose (fat), bone marrow and umbilical cord derived options available.

Needle Free Air-Jet Pain pre Injections option for procedures.

We perform our procedures at a private Room by Medical Office Towers* in Los Angeles, with easy access to many Hospitals, Ranked in the top 10 USA Hospitals.

Our physician is a recipient of the prestigious UCLA Vice Provost Prize, the Motif Award sponsored by Walt Disney, and Altamed PACE Clinical Quality Award. His research published in the UCLA Science Journal had also been awarded the best research article of the year. Participate in conferences & up to date with the latest research. Expertise in Geriatric & Chronic Diseases.

FDA compliant with strict sterile protocols, research participation and no modification of products.

Research Papers

For years, we have done thorough research, gathered results data of patients, and gotten reviews from patients, all with a single purpose in mind – to give you adequate information that will allow you make the best decision with regards to treatment of your condition.

 

1. Adipose-derived stem cells added to platelet-rich plasma for chronic skin ulcer therapy

Adipose-derived stem cells (ASCs) hold great promise for regenerative medicine applications due to their ability to promote the healing process through in situ differentiation and secretion of paracrine factor. The aim of this research was to present a clinical adjunct for chronic skin wound therapy based on ASCs added to platelet-rich plasma (PRP), to obtain an enhanced PRP (e-PRP). For 18 months, 24 control-group patients with 31 chronic skin ulcers were treated with standard wound care, while 16 experimental-group patients with 21 chronic skin ulcers were treated with standard wound care and 1 e-PRP injection. The patients were randomly assigned to the control or experimental group. Outpatients had weekly follow-up visits where they were subjected to standard treatment and the wound healing process was assessed. At the end of the study, the control and experimental groups had similar healing rates but wound closure rates were significantly different (P = 0.0257): 0.0890 cm(2) x day and 0.2287 cm(2) x day respectively, resulting in a faster recovery for the group treated with e-PRP. No side effects were reported. In the authors’ experience, e-PRP significantly enhanced wound closure rates when compared to standard wound care, without causing any serious complications. This finding highlights e-PRP as a valuable resource for chronic wound treatment. Link to the study >>>>> HERE

2. Platelet rich plasma: New insights for cutaneous would healing

The overall increase of chronic degenerative diseases associated with ageing makes wound care a tremendous socioeconomic burden. Thus, there is a growing need to develop novel wound healing therapies to improve cutaneous wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining interest due to its potential to stimulate and accelerate the wound healing process. The cytokines and growth factors forming PRP play a crucial role in the healing process. This article reviews the emerging field of skin wound regenerative therapies with particular emphasis on PRP and the role of growth factors in the wound healing process. Link to the study >>>>> HERE

3. Adipose-derived stem cells for treatment of chronic ulcers: current status

Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov. A total of nine clinical trials and fourteen registered trials were included. The studies were significantly different in terms of study design and patient population, and the overall quality of the studies was low to moderate. Despite the overall low study quality and the significant differences between the studies, some conclusions were consistent: ADSCs are safe, improve the healing of chronic ulcers, and reduce pain. As these results are consistent despite the shortcomings of the studies, they appear to highlight the efficacy of ADSCs in the treatment of chronic ulcers. Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers. Link to study >>>>> HERE

4. Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg. 2007; 9(3):174-183.

The goal of this study was to compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers. A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh, and an antibiotic ointment and/or a semiocclusive dressing was applied on the other thigh. Healing was monitored for spontaneous wound closure by clinical assessment and by digital photographs over 6 months. Over 35 days, 64 serial dermal biopsy specimens (6 mm diameter) were analyzed (using hematoxylin-eosin, Mason trichrome, CD-34, and Ki-67 stains) to measure differences between treated and control sites for cellularity, granulation formation, vascularity, epithelialization, and cellular replication.

Over a 42-day period, the APG-treated sites had statistically increased wound closure compared with controls by visual clinical assessment and by digital planimetry photographic measurements (P<or=.02). On day 17, the percentage of closure was 81.1% +/- 2.5% (mean +/- SE) for the APG-treated sites and 57.2% +/- 5.9% for the control sites. Also, the APG wound closure velocities were significantly faster than those of the controls (P = .001). Histologically, over time, the APG-treated sites had similar cellularity, cellular replication, granulation tissue, vascularity, and epithelialization compared with controls. However, when the platelet count in the gel was more than 6 times the baseline intravascular platelet count in some subjects, epithelialization and granulation formation appeared 3 days earlier in the APG-treated group. Furthermore, in vitro testing of supplemental APG showed increased endothelial cell proliferation compared with controls (P<.04). This pilot study provides preliminary evidence that topical APG may hasten wound closure in full-thickness dermal wounds in healthy individuals.

Link to the study >>>>> HERE

5. Sclafani AP, Romo TR III, Ukrainsky G, et al. Modulation of wound response and soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate. Arch Facial Plast Surg. 2005; 7(3):163-169.

The goal of the study was to evaluate the modulation of wound healing and soft tissue ingrowth in synthetic and allogeneic implants with platelet gel. Attempts to influence wound healing with exogenous growth factors are highly dependent on the timing and dosing of treatment. Platelet gel made from autologous platelet concentrate (PC) and activated with calcium thrombin is increasingly used to enhance healing of surgical and chronic wounds, based on the assumption that proteins found in the blood can promote healing.

Link to the study >>>>> HERE

6. O’Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lowerextremity ulcers. Wound Repair Regen. 2008; 16(6):749-756.

A novel autologous platelet-rich fibrin matrix membrane (PRFM) was assessed for the ability to facilitate healing in patients with chronic lower-extremity ulcers. Preliminary data are presented from a prospective trial (n=21). Twelve patients were identified with 17 venous leg ulcers (VLU) and nine bearing 13 nonvenous lower-extremity ulcers. Before enrollment, the patients were evaluated for vascular status and received appropriate surgical intervention to optimize arterial and venous circulatory status. None of the ulcers had responded to a variety of standard treatments from 4 months to 53 years. Initial ulcer size ranged from 0.7 to 65 cm(2) (mean, 11.2 cm(2)). Each PRFM-treated patient received up to three applications of either a 35 or 50 mm fenestrated membrane, depending on initial ulcer size. The primary endpoints were percent and rate of complete closure as measured by digital photography, computerized planimetery, and clinical examination. Patients were followed weekly for 12 weeks with a follow-up visit at 16 weeks. At each 4-week interval, the extent of healing was assessed, and those patients with >50% reduction in wound area were allowed to continue to complete closure. Patients with <50% closure received repeated applications. Complete closure was achieved in 66.7% of the VLU patients (64.7% of treated ulcers) in 7.1 weeks (median, 6 weeks) with an average of two applications per patient. Forty-four percent complete closure was seen with non-VLU patients (31% of treated ulcers). From the results of this small-scale pilot study, PRFM shows significant potential for closing of chronic leg ulcers. Link to the study >>>>> HERE

Review & Testimonials/Case Examples

“Forty-four percent complete closure was seen with non-VLU patients (31% of treated ulcers). From the results of this small-scale pilot study, PRFM shows significant potential for closing of chronic leg ulcers.”

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Introduction About the Topic

Stem Cell For Wound & Ulcer Healing

Sometimes we have wounds that fail to heal after a specified period of time. Such wounds that refuse to heal at the right time are known as chronic wounds. More specifically, a chronic wound is that which does not heal nor advance through the normal healing phases after three months. The healing process stalls at the inflammatory stage of healing. So many factors contribute to the inability of the wound to heal. These include autoimmune dysfunction, ischemia (poor blood flow), malnutrition, radiation burns, diabetes, lupus, and other degenerative conditions. However, this problem can be solved with adult stem cell therapy. This is a new option that has been made available for patients who have chronic wounds.

Current Treatment at Other Clinics

Current treatment involves using medications and at times injection.  These treatments are considered a patch up of the problem without treating the root cause of the problem.  Medications & steroids have many side effects including weight gain & increased blood sugar from steroids, damage to kidneys, heart, stroke & gastric ulcer.  Surgery can be very debilitating with prolong downtime during recovery requiring at times prolonged bed rest & even residing in nursing home for recovery.  It also entails a lot of risk including risk of infection, bleeding, poor surgical outcome to name a few.  Stem cells however, reduce the inflammation and pain that are typical of these conditions. Current ongoing research on the effect of stem cells has shown positive results.

We are different from many other clinics who offer stem cell or PRP.   Other may also not offer option of bone marrow derived stem cell, Adipose derived stem cell & umbilical cord stem cell.  They in effect expose patients to more invasive treatments like drilling bones without offering other easier options.  They also may use xray with unnecessary radiation for injections that can be easily avoided in most cases by using ultrasound.  Furthermore, they may not have proper knowledge of how other modalities can enhance the effects of Stem Cells.  These other modalities are used by us to focus on the whole body and treating different parts of it instead of just treating one out of several diseased structures in the body. 

Safe Non Surgical Option

We use a combination of newest cutting edge technology in regenerative medicine to stimulate body’s own repair ability to reverse aging and damage.   We use Stem Cells as part of treatment plan designed by the doctor to treat the body.    These are safe investigational treatments that have shown very promising & safe results in thousands of treatments over the 10-20 years in Europe and USA.   They don’t involve using any medications or drugs.  

 

What Does Stem Cell Therapy Do?


The researchers believe that the therapy works by:

Releasing cytokines into the body to prevent further damage and inflammation.

Preventing inflammation that can make the disease worse.

Creating healthy new tissues or missing or damaged products in body.

Many patients experience improvements in the treated area and other areas, like in a Mayo Clinic study where patients benefited in both knees after experiencing injections in only one.

HOW DOES STEM CELL THERAPY HELP IN CHRONIC WOUNDS?

For a wound to heal effectively, it must receive good and rich blood supply. Blood is loaded with nutrients and oxygen, both of which are vital to restoration of health. As a matter of fact, without oxygen and nutrients, your wounds cannot heal. Stem cells present in the human body have the ability to stimulate the development of new blood vessels. This process in itself is important for wound healing.

Apart from stem cells, the fatty tissue in your body contains many cells that secrete growth factors. Growth factors are also important to wound healing. Development of new blood vessels along with the activities of growth factors greatly enhances the healing of chronic wounds. They do this through the following processes:

  • Decreased pain
  • Reduced inflammation
  • Decreasing the depth and the diameter of the wound or ulcer
  • Improves the cosmetic appearance of the site of injury
  • Accelerates complete closure of the wound.

 

Stem cell treatment for chronic wound and ulcer is a quick procedure. Why? Because we harvest the stem cells, and inject it into you on the same day. It is important to note that we use embryological stem cells. Complete stem cell treatment for chronic wounds and ulcers takes place over a course of one week. This depends on the patient’s situation.  Stem cell injection for Wound & Ulcer injury would comprise of a pre-injection, embryological stem cell injection procedure, accompanied by post-injection of platelets after a few days.

PRP FOR WOUND AND ULCER HEALING

PRP is unique. What makes it unique? Because the healing substances that are used for treatment are extracted from your own body. PRP is important for the healing of wounds and ulcers. It enhances recovery of all injured tissues including joints, ligaments, tendons, and muscles.

Platelet rich plasma is actually plasma extracted from your blood. The plasma is then enriched with a large concentration of platelets. Platelet rich plasma is created by separating the white and red blood cells from the plasma. PRP is also rich in growth factors and cytokine. Cytokines are specialized cells that enhances the healing of wounds and soft tissues.

HOW DOES PRP ENHANCE HEALING OF WOUNDS AND ULCERS?

The basic principle behind the actions of PRP is this…it enhances the healing of wounds through introduction of concentrated platelets. We know that platelets are those cells in your blood that helps blood to clot after you might have sustained an injury. Platelets are also loaded with the following biochemical molecules:

  • Signaling molecules
  • Regulatory molecules
  • Growth factors

These molecules are all important for the healing and recovery of injured cells and tissues.

APART FROM WOUNDS, WHAT ELSE DOES PLATELET RICH PLASMA HELP TO HEAL?

Research and clinical experience has shown that PRP facilitates the healing of muscles, joints, ligaments, and other tissues. It also facilitates the healing of many skin issues such as:

  • Ulcers of the leg (arterial and venous ulcers)
  • Bedsores
  • Foot ulcers (mostly linked to diabetes)
  • Skin grafts
  • First degree and second degree burns
  • Surgical incisions
  • Healing of scars and cosmetic treatment

HOW DOES PRP HELP THE WOUND-HEALING PROCESS?

PRP contains growth factors which it releases into soft tissues. By this process, the concentration of platelets is increased, and this enhances the healing and recovery of tissues.

PRP contains important growth factors such as:

  • Fibroblast growth factor-2
  • Epidermal growth factor
  • Insulin-like growth factor
  • Vascular endothelial growth factor
  • Transforming-growth-factor-beta
  • Platelet-derived growth factor

These growth factors enhances the healing process through the following mechanisms:

  • It attracts stem cells and then triggers the process of differentiation
  • Acts as anti-inflammatory agent by suppressing the release of certain proteins that attracts macrophages.
  • It facilitates the formation of new blood cells and tissue healing

HOW THEN IS THIS PROCEDURE DONE?

The use of platelet rich plasma is entirely an autologous process. This means that the healing substances are extracted from your own blood. Our doctors will treat you using the following process:

  • A small quantity of blood is drawn from your arm
  • The blood is centrifuged, resulting in the separation of red and white blood cells from the platelets and plasma.
  • Plasma with high concentration of platelets is then separated from the blood
  • The platelets are then activated through the addition of an activating agent like calcium chloride.
  • This PRP is then injected into the site of injury, thus triggering the healing process.

 

IS THE PRP TREATMENT SAFE?

Of course PRP treatment is safe. Platelets enhance the blood clotting process. Without platelets, your body will be unable to form blood clots, prevents excessive bleeding and wound healing.

Because platelet rich plasma is an autologous process, there will be no need to consider the formation of antibodies. This makes it widely accepted by patients. Also, there is no need to worry about transmissible diseases as autologous PRP is free from:

  • HIV
  • Hepatitis B
  • Hepatitis C

With respect to immunology, PRP is neutral and does not constitute a threat of hypersensitivity, allergy, or reaction to foreign bodies.

We understand that PRP injection is a very important procedure, and a sensitive one at that, one requiring expertize, and so we have well-trained doctors that will treat you, resulting in full recovery from ulcers and wounds within a reasonable timeframe.

What makes our facility special?

At our Los Angeles facility, we have invented modern approaches to medical care. Our approach to treatment is second to none. The harvesting process does not involve any form of drilling, and the stem cells are purified and tested for quality before injection. We also employ ultrasound to help in the precise location of high dose stem cells at the required site. These cells will then perform their duty, promoting the formation of new tissues. We are experts in this and has seen positive outcome with our treatments. Our licensed physicians have undergone intense training running into thousands of hours, and so, you can be sure that you are in safe hands.

Needle Free Air-Jet Pain pre Injections

Our doctor is one of the few doctors in USA & Los Angeles offering the new technology of needle free injection.  Located in Beverly Hills adjacent fancily we serve customers from Los Angeles, Orange county and Ventura County.  We are premier destination for out of town customers from Nevada, Arizona, San Francisco, San Diego & Oregon.  We are proud to be the premier location for the advancement in medical technology and patient comfort in Southern California.  We have introduced our needle free injector for a more comfortable and painless experience.  There are many advantages in using needle free injectors and it is elected to replace traditional injections in the near future.  They allow injections with very small doses of medicine with significantly faster onset and a lot less pain and discomfort.

Our Office is Located at one of America’s Top Health Venue in Beverly Hills Adjacent        

We perform our procedures at a private Room by Medical Office Towers* in Los Angeles, with easy access to many Hospitals, Ranked in the top 10 USA Hospitals.  These hospitals are ranked nationally in 11 specialties and has been named to the “Honor Roll” in U.S. News & World Report’s “Best Hospitals 2016-17.”

In 2014-15, these medical centers in the Los Angeles area to win the Consumer Choice Award for:

  • Best Overall Healthcare Quality
  • Best Image
  • Best Doctors
  • Best Nurses

You Are in Good Hands!

Dr. Padra Gad Nourparvar is a recipient of the prestigious UCLA vice provost prize, the Motif Award sponsored by Walt Disney, and Altamed PACE Clinical Quality Award. His research published in the ULCA Science Journal had also been awarded the best research article of the year.

He has special affiliation to Cedar Sinai, White Memorial, CHLA, and other top medical institutions. He is a diplomat of Board of Osteopathic FP & Licensed by the Medical Board of California Physician & Surgeons. He is trained by the NY College of Osteopathic Medicine in osteopathic manipulation. Also, he has trained in several Physical Medicine & Rehab hospitals & research facilities including UCLA, UC Irvine, Mount Sinai,  NYU.

As a plus, he is one of the few and first doctor in USA trained in ultrasound guided joint injection for precision guided accurate injections and needle free air-jet injector.  Dr. Padra Nourparvar has been a pioneer in medical technology and advancements including stem cell. He is passionate about natural treatment with very minimal use of medication while also avoiding unnecessary surgical procedures. He is well versed in the latest and most effective anti-aging treatment using PRP and stem cell. He has extensive expertise and many years of experience in geriatrics & chronic disease management.

 

Frequently Asked Questions

What are platelets?

Platelets are cell fragments, small and without color. They do not have a nucleus and are found in the blood. These cells are indispensable in the blood clotting process. They are also important in the release of growth factors.

What is PRP?

The human blood has two major components – the cellular component (made up of red blood cells, white blood cells, and platelets), and the liquid component which is the plasma. PRP is plasma that is rich in platelets. The number of platelets in the plasma is much more than what you would find in blood.

What are growth factors?

Growth factors are important for the repair of wounds and ulcers. As a matter of fact, they initiate the repair process. They are derived from platelets and they play key roles in bone regeneration, repair of soft tissue, stimulates the process of wound healing, and development of blood vessels.

Is PRP safe?

Yes! PRP is very safe and recommended for clinical usage.

 

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Stem Cell & PRP Institute of L.A.| General & Men’s Health, Pain & Aesthetics 

 

Dr. Padra Gad Nourparvar

Board Certified in FM: Adults & Pediatrics

Cedars Sinai Medical Office Towers (New Clinic), 8631 West 3rd Street #545E, Los Angeles, CA.

Cedars Sinai Medical Towers Surgical Suit (Old Clinic), 8635 W 3rd St #880W, Los Angeles, CA 90048

(310) 361-5480

Open Hours

Mon – Thu — 8:30am – 6:00pm
Friday — 8:30am – 4:30pm

 

*Claims are based on ongoing research. Please note that results may vary based on a patient’s medical conditions & age and may require a few months & repeated treatments to obtain. Treatments are considered investigational & these claims have not been verified by the FDA.  No claim for curing or treating of any condition is made.  A consultation with our trained Board Certified physician is scheduled before starting your treatments to confirm the procedure would be appropriate for you. 

Stem Cell

Important Disclosure:

Our clinic is not offering stem cells or stem cell therapy as a cure for any condition, disease, or injury. No statements or implied treatments on this website have been evaluated or approved by the FDA. This website contains no medical advice.  We may use biologics from umbilical cord blood, nanofat and bone marrow aspirate that potentially contain stem cells.   Many of information and treatments maybe investigational and may require participation in a research program.  No results or specific outcomes are guaranteed.  Please use this site as an educational source and consult with a physician about options and treatments.