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Highlights

Review & Testimonials/Case Examples

Research

Introduction About the Topic

Current Treatments and Side Effects

How stem cells & Other Treatments Work

Highlights of Our Facility

FAQs

STEM CELL THERAPY FOR PERIPHERAL ARTERY DISEASE

Highlights

Safe Non Invasive & Natural Option*

Avoid surgery toxic medications and injections.

Stimulates the Body’s Own Healing Ability*

Helps balance body in a process called regeneration.*

Preventing inflammation.

A Natural Treatment*

No down time.

Return to work the same day.   

 

Ongoing Research Participation

We enroll our patients in ongoing research protocols and data system for collection & analysis of best outcome results from therapies. We keep records of procedures performed in our outcomes database & in shared and published databases. Patients are always treated with the best protocols & treatments based on the latest research data & informed consent on investigational nature of treatments.  Strict sterile protocols & universal precautions are followed by out office and staff.

The Difference

Treatments at Other Clinics:

"Patch up" treatments like, addicting pain medications, Steroid injection, Medications (with many side effects including weight gain & increased blood sugar, damage to kidneys, heart, stroke & gastric ulcer from NSAIDs.)

Not experienced in management of chronic diseases.

May not offer option of different bone marrow types. (only offer drilling bones or low quality umbilical stem cells.)

May use poorly trained non-physician assistants to evaluate & perform injections.

Not FDA compliant.

Treatments at Our Clinic:

Treating the root cause of the problem by regenerating the damaged regions and balancing immune system. Good safety profile with body products from own body.

Other modalities like IV Vitamin Therapy to focus on the whole body and treating different parts of it instead of just treating one out of several diseased structures in the body.

Several types of stem cell including Adipose (fat), bone marrow and umbilical cord derived options available.

Needle Free Air-Jet Pain pre Injections option for procedures.

We perform our procedures at a private Room by Medical Office Towers* in Los Angeles, with easy access to many Hospitals, Ranked in the top 10 USA Hospitals.

Our physician is a recipient of the prestigious UCLA Vice Provost Prize, the Motif Award sponsored by Walt Disney, and Altamed PACE Clinical Quality Award. His research published in the UCLA Science Journal had also been awarded the best research article of the year. Participate in conferences & up to date with the latest research. Expertise in Geriatric & Chronic Diseases.

FDA compliant with strict sterile protocols, research participation and no modification of products.

Research Papers

For years, we have done thorough research, gathered results data of patients, and gotten reviews from patients, all with a single purpose in mind – to give you adequate information that will allow you make the best decision with regards to treatment of your condition.

 

Clinical Trials of Adult Stem Cell Therapy for Peripheral Artery Disease

Peripheral artery disease (PAD) refers to noncoronary vascular disease affecting the peripheral arteries. Most commonly the term is applied to occlusive arterial disease affecting the limb arteries, typically due to atherosclerosis. Preclinical studies indicate that a variety of stem cell therapies provide growth factors and cytokines for therapeutic angiogenesis. Small clinical trials with bone marrow mononuclear cells, as well as other cell types, have shown promise. However, mechanisms of therapeutic effect, if any, are not understood. Definitive clinical trials are needed to determine if there are any beneficial effects on functional capacity or morbidity. Link to the study >>>>> HERE

 

Cell Therapy of Peripheral Arterial Disease: From Experimental Findings to Clinical Trials

The age-adjusted prevalence of peripheral arterial disease in the US population was estimated to approach 12% in 1985, and as the population ages, the overall population having peripheral arterial disease is predicted to rise. The clinical consequences of occlusive peripheral arterial disease include intermittent claudication, that is, pain with walking, and critical limb ischemia (CLI), which includes pain at rest and loss of tissue integrity in the distal limbs, which may ultimately lead to amputation of a portion of the lower extremity. The risk factors for CLI are similar to those linked to coronary artery disease and include advanced age, smoking, diabetes mellitus, hyperlipidemia, and hypertension. The worldwide incidence of CLI was estimated to be 500 to 1000 cases per million people per year in 1991. The prognosis is poor for CLI subjects with advanced limb disease. One study of >400 such subjects in the United Kingdom found that 25% required amputation and 20% (including some subjects who had required amputation) died within 1 year. In the United States, ≈280 lower-limb amputations for ischemic disease are performed per million people each year. The first objective in treating CLI is to increase blood circulation to the affected limb. Theoretically, increased blood flow could be achieved by increasing the number of vessels that supply the ischemic tissue with blood. The use of pharmacological agents to induce new blood vessel growth for the treatment or prevention of pathological clinical conditions has been called therapeutic angiogenesis. Since the identification of the endothelial progenitor cell in 1997 by Asahara and Isner, the field of cell-based therapies for peripheral arterial disease has been in a state of continuous evolution. Here, we review the current state of that field. Link to the study >>>>> HERE

Review & Testimonials/Case Examples

” Preclinical studies indicate that a variety of stem cell therapies provide growth factors and cytokines for therapeutic angiogenesis. Small clinical trials with bone marrow mononuclear cells, as well as other cell types, have shown promise.”

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Introduction About the Topic

What is peripheral artery disease?

Peripheral Artery Disease, abbreviated PAD is a disorder of the blood vessels that lie outside the brain and the heart. Peripheral artery disease is caused by the accumulation of fat in the arteries. Peripheral artery disease is also referred to as peripheral vascular disease or peripheral arterial disease.

Blood vessels that are affected by peripheral artery disease are often constricted (that is, they get narrow). This reduces the flow of blood to the stomach, kidneys, the arms, and of course, the legs.

A survey has shown that about 8.5 million American citizens are affected by peripheral artery disease. Also, about 10-20% of US citizens above the age of 60 are affected by the disease.

Peripheral artery disease contributes to stroke and heart attack. The prevalence of the disease is higher in African-Americans compared to other races. It is also more prevalent in men than in women. Smokers are also at high risk of the disease.

The symptoms of peripheral artery disease can be improved upon by physical activity.

How do i know that i have peripheral artery disease?

Research has shown that up to 50% of those affected by the disease do not even know that they have the condition. This is because most patients do not have any symptoms. The symptoms of this disorder include:

  • Loos of hair on the forelimbs and the hind limbs
  • Weakness of the legs
  • Pains in the calf and thigh muscles when climbing the stairs or when walking. This is known in clinical terms as intermittent claudication.
  • A cold feeling in the lower leg or in the foot
  • The legs feel numb
  • Slow growth of the toenails
  • Brittle toenails
  • Ulceration of the feet and the legs. This usually takes some time to heal.
  • A bluish tint or paleness of the skin of the legs.
  • Some men may experience an ED (impotence)

What are the causes of peripheral artery disease?

Peripheral artery disease is mostly caused by atherosclerosis. Atherosclerosis is not an acute condition. It occurs over time, and involves the accumulation of fatty substances inside the arteries.

Some minor risk factors for peripheral artery disease include limb injury, blood clots in the arteries, and a distorted anatomy of the ligaments and the limbs.

Other risk factors include smoking, diabetes, high blood pressure, obesity, and a high level of homocysteine or C-reactive protein.

Peripheral artery disease can be diagnosed through following tests:

  • Computed tomographic angiography
  • Ankle-brachial index
  • Doppler and ultrasound imaging
  • Magnetic resonance angiography

If this condition is not diagnosed or treated on time, it may result in very risky complications such as the loss of a leg, carotid atherosclerosis, or a high risk of coronary artery disease.

Current Treatment at Other Clinics

Recommended guidelines by the American College of Cardiology Foundation and the American Heart Foundation for the management of peripheral artery disease include:

  • Changes and adjustment in diet
  • Regular physical activity
  • Medications such as Cilostazol and pentoxifylline for those with intermittent claudication, and Ramipril, and ACE inhibitor that improves walking.

Current treatment involves using medications and at times injection.  These treatments are considered a patch up of the problem without treating the root cause of the problem.  Medications & steroids have many side effects including weight gain & increased blood sugar from steroids, damage to kidneys, heart, stroke & gastric ulcer.  Surgery can be very debilitating with prolong downtime during recovery requiring at times prolonged bed rest & even residing in nursing home for recovery.  It also entails a lot of risk including risk of infection, bleeding, poor surgical outcome to name a few.  Stem cells however, reduce the inflammation and pain that are typical of these conditions. Current ongoing research on the effect of stem cells has shown positive results.

We are different from many other clinics who offer stem cell or PRP.   Other may also not offer option of bone marrow derived stem cell, Adipose derived stem cell & umbilical cord stem cell.  They in effect expose patients to more invasive treatments like drilling bones without offering other easier options.  They also may use xray with unnecessary radiation for injections that can be easily avoided in most cases by using ultrasound.  Furthermore, they may not have proper knowledge of how other modalities can enhance the effects of Stem Cells.  These other modalities are used by us to focus on the whole body and treating different parts of it instead of just treating one out of several diseased structures in the body. 

Safe Non Surgical Option

We use a combination of newest cutting edge technology in regenerative medicine to stimulate body’s own repair ability to reverse aging and damage.   We use Stem Cells as part of treatment plan designed by the doctor to treat the body.    These are safe investigational treatments that have shown very promising & safe results in thousands of treatments over the 10-20 years in Europe and USA.   They don’t involve using any medications or drugs.  

 

What Does Stem Cell Therapy Do?


The researchers believe that the therapy works by:

Releasing cytokines into the body to prevent further damage and inflammation.

Preventing inflammation that can make the disease worse.

Creating healthy new tissues or missing or damaged products in body.

Many patients experience improvements in the treated area and other areas, like in a Mayo Clinic study where patients benefited in both knees after experiencing injections in only one.

Can peripheral artery disease be treated with stem cells?

There is a continual exploration of stem cell therapies – both pre-clinically and clinically. These studies have shown that mesenchymal stem cells under optimum conditions may help to enhance the formation of new blood vessels, while boosting perfusion of blood in ischemic tissues through the secretion of growth factors such as HGF, FGF, VEGF, ANG-1, and SDF-1. A number of clinical studies have been done to prove this fact.

At our facility, stem cell therapy for myocardial infarction involves injection of mesenchymal stem cells harvested from the embryo (human umbilical cord tissue).

We use stem cells from human umbilical cord tissue (allogenic mesenchymal stem cells).

The mesenchymal stem cells are derived from umbilical donated after normal, healthy births. The medical history of each mother is screened. Test for infectious diseases is done, and each family gives their consent before donating.

All stem cells derived from umbilical cords are screened for infectious ailments. Screening is done to International Blood Bank Standards prior to usage.

As a matter of fact, a very low percentage of donated umbilical cords scale through this screening process.

What makes our facility special?

At our Los Angeles facility, we have invented modern approaches to medical care. Our approach to treatment is second to none. The harvesting process does not involve any form of drilling, and the stem cells are purified and tested for quality before injection. We also employ ultrasound to help in the precise location of high dose stem cells at the required site. These cells will then perform their duty, promoting the formation of new tissues. We are experts in this and has seen positive outcome with our treatments. Our licensed physicians have undergone intense training running into thousands of hours, and so, you can be sure that you are in safe hands.

Needle Free Air-Jet Pain pre Injections

Our doctor is one of the few doctors in USA & Los Angeles offering the new technology of needle free injection.  Located in Beverly Hills adjacent fancily we serve customers from Los Angeles, Orange county and Ventura County.  We are premier destination for out of town customers from Nevada, Arizona, San Francisco, San Diego & Oregon.  We are proud to be the premier location for the advancement in medical technology and patient comfort in Southern California.  We have introduced our needle free injector for a more comfortable and painless experience.  There are many advantages in using needle free injectors and it is elected to replace traditional injections in the near future.  They allow injections with very small doses of medicine with significantly faster onset and a lot less pain and discomfort.

Our Office is Located at one of America’s Top Health Venue in Beverly Hills Adjacent        

We perform our procedures at a private Room by Medical Office Towers* in Los Angeles, with easy access to many Hospitals, Ranked in the top 10 USA Hospitals.  These hospitals are ranked nationally in 11 specialties and has been named to the “Honor Roll” in U.S. News & World Report’s “Best Hospitals 2016-17.”

In 2014-15, these medical centers in the Los Angeles area to win the Consumer Choice Award for:

  • Best Overall Healthcare Quality
  • Best Image
  • Best Doctors
  • Best Nurses

You Are in Good Hands!

Dr. Padra Gad Nourparvar is a recipient of the prestigious UCLA vice provost prize, the Motif Award sponsored by Walt Disney, and Altamed PACE Clinical Quality Award. His research published in the ULCA Science Journal had also been awarded the best research article of the year.

He has special affiliation to Cedar Sinai, White Memorial, CHLA, and other top medical institutions. He is a diplomat of Board of Osteopathic FP & Licensed by the Medical Board of California Physician & Surgeons. He is trained by the NY College of Osteopathic Medicine in osteopathic manipulation. Also, he has trained in several physical medicine & rehab hospitals & research facilities including UCLA, UC Irvine, Mount Sinai,  NYU.

As a plus, he is one of the few and first doctor in USA trained in ultrasound guided joint injection for precision guided accurate injections and needle free air-jet injector.  Dr. P. Nourparvar has been a pioneer in medical technology and advancements including stem cell. He is passionate about natural treatment with very minimal use of medication while also avoiding unnecessary surgical procedures. He is well versed in the latest and most effective anti-aging treatment using PRP and stem cell. He has extensive expertise and many years of experience in geriatrics & chronic disease management.

 

Frequently Asked Questions

What is peripheral artery disease?

Peripheral artery disease is defined by the American Heart Association as the constriction of arteries that leads from the heart to the arms, stomach, arms, and legs. The legs are mostly affected by this disease. The major cause of PAD is accumulation of plaque in the arterial walls.

Is peripheral artery disease a long-lasting condition?

Yes! Peripheral artery disease is a chronic condition, because it does not present immediately and also persists after treatment.

What causes the pain during walking?

For your muscles to function efficiently, it need blood. If the flow of blood is restricted (as it occurs during PAD), then your muscles will be deprived of oxygen. This will cause the pain. The pain reduces when you stop using the muscles because the demand for blood has reduced.

Is it possible for people to have this disease and not know about it?

A study by the National Center for Biotechnology Information has shown that patients with PAD do not have symptoms in most cases. As such, they are not aware that they have the condition.

 

Why is it important to diagnose and treat this disease?

About 20 percent of US citizens above the age of 50 have peripheral artery disease. It is important to diagnose and treat this condition to prevent permanent damage to the limbs and fatal cardiovascular conditions.

 

From where do stem cells originate?

Stem cells are present in many tissues and organs. The bone marrow is the richest source of stem cells. However, the most convenient region for harvesting is the umbilical cord.

 

How are adult stem cells harvested?

The physician draws the stem cells from the umbilical cord. The stem cells and the growth factors will then be concentrated using specially designed equipment. The physician then injects the cells into the destined regions.

What’s the Cost of Stem Cell Injection?

The cost of treatment depends on the procedure performed.  We often offer discounts for returning customers or larger packages of treatment using repeated injections or combining different treatments.  We also offer a price match policy on comparing treatments done by board certified physicians.  We also have interest free payment plan options including care credit for qualifying patients. A limited number of insurance companies and Workers compensation may at times cover some of the expenses.  You may be able to get reimbursed by your insurance for your doctor visits & ultrasound cost. The consultation fee can be deducted from your future procedures, making your consolation free of cost to you.

Book a consultation with our experts to see the type of procedure that is right for you.

 

When will my results show up?

Stem cell therapy relies on your own regenerative healing to occur. We are all different and so is our healing process. Some patients may begin to see their results within few weeks while others may require some months. The time taken for healing to manifest also depends on the severity of the disease.

What can stem cell therapy potentially treat?

Stem cell therapy is beneficial to a number of conditions such as osteoarthritis, erectile dysfunction, joint pain, renal disease, neurological disorders, autism, cellular rejuvenation, etc.

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Stem Cell & PRP Institute of L.A.| General & Men’s Health, Pain & Aesthetics 

 

Dr. Padra Gad Nourparvar

Board Certified in FM: Adults & Pediatrics

Cedars Sinai Medical Office Towers (New Clinic), 8631 West 3rd Street #545E, Los Angeles, CA.

Cedars Sinai Medical Towers Surgical Suit (Old Clinic), 8635 W 3rd St #880W, Los Angeles, CA 90048

(310) 361-5480

Open Hours

Mon – Thu — 8:30am – 6:00pm
Friday — 8:30am – 4:30pm

 

*Claims are based on ongoing research. Please note that results may vary based on a patient’s medical conditions & age and may require a few months & repeated treatments to obtain. Treatments are considered investigational & these claims have not been verified by the FDA.  No claim for curing or treating of any condition is made.  A consultation with our trained Board Certified physician is scheduled before starting your treatments to confirm the procedure would be appropriate for you. 

Stem Cell

Important Disclosure:

Our clinic is not offering stem cells or stem cell therapy as a cure for any condition, disease, or injury. No statements or implied treatments on this website have been evaluated or approved by the FDA. This website contains no medical advice.  We may use biologics from umbilical cord blood, nanofat and bone marrow aspirate that potentially contain stem cells.   Many of information and treatments maybe investigational and may require participation in a research program.  No results or specific outcomes are guaranteed.  Please use this site as an educational source and consult with a physician about options and treatments.